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Researchers with gut health concerns should evaluate whether cagrilintide effects would complement or complicate their existing conditions

Abbreviations AD: Alzheimers disease ASD: Autism spectrum disorder BBB: Bloodbrain barrier BDNF: Brain-derived neurotrophic factor CNS: Central nervous system CRF: Corticotropin-releasing factor EAE: Experimental autoimmune encephalomyelitis ENS: Enteric nervous system FMT: Fecal microbiota transplantation GABA: Gamma-aminobutyric acid GLP-1: Glucagon-like peptide-1 HD: Huntingtons disease HPA axis: Hypothalamicpituitaryadrenal axis LPS: Lipopolysaccharide MGBA: Microbiotagutbrain axis MS: Multiple sclerosis PD: Parkinsons disease SCFAs: Short-chain fatty acids TMA: Trimethylamine TMAO: Trimethylamine N-oxide TNF-: Tumor necrosis factor-alpha Th17: T helper 17 cells Tregs: Regulatory T cells References Wilson DM III, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I

The peptide also influences neurotransmitter systems, particularly dopaminergic and GABAergic pathways, contributing to its neuroprotective effects

Burns and Trauma 10, tkac022